Drug Delivery & Targeting (Track)

Design, Development and Evaluation of Mucoadhesive Buccal Tablets of Perindopril

Bhanja Satyabrata
Department of Pharmaceutics, Jeypore College of Pharmacy, Jeypore(k), Orissa,india

Abstract:

The aim of the present study was to prepare and evaluate a mucoadhesive buccal tablets containing antihypertensive drug, Perindopril to avoid early metabolism and improve its bioavailability. The tablets were prepared by direct compression method containing Polyethylene oxide and Carnauba wax. The tablets were sintered at temperatures 600 C and 700C for 1.5 hr and 3 hr. The sintered tablets were tested for weight variation, hardness, surface pH, drug uniformity, swelling index, bioadhesive strength, in-vitro drug dissolution and stability studies. Fourier Transform Infrared Spectrophotomer (FTIR) and Differential Scanning Calorimetry(DSC) studies showed no evidence of interactions between drug, polymers and excipients. The in- vitro release of Perindopril was performed under sink conditions (Phosphate buffer PH 6.8, 37±0.5 ºC, rpm 50) using USP-XXIV dissolution apparatus. The best in-vitro drug release profile was achieved with the formulation which contained the drug, polyethylene oxide and carnauba wax in the ratio of 1:15:10 and sintered at 600C for 1.5 hr.The surface pH, bioadhesive strength and swelling index of formulation was found to be 6.27, 34.8 gm and 179.31. The tablets containing 4 mg of Perindopril exhibited 8 hrs sustained drug release (98 %) with desired therapeutic concentration following diffusive mechanism with first order release kinetics.

Key words; Perindopril, sintering, Bioadesive strength, Swelling index, drug release.